MYSM1 Polyclonal Antibody

Reddot Biotech

MYSM1 Polyclonal Antibody

5

0.5 mg/ml

MYSM1

Myb like, SWIRM and MPN domains 1

2ADUB; 2A-DUB; BMFS4; deubiquitinase MYSM1; histone H2A deubiquitinase MYSM1; myb-like, SWIRM and MPN domain-containing protein 1

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones

-20°C

12352203