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ProductsBack/Myxochelin A [120243-02-9]
Chemical Structure
Chemical Structure
Chemical Structure

Myxochelin A [120243-02-9]

Research Use Only
AG-CN2-0470
AdipoGen Life Sciences
CAS Number120243-02-9
DownloadMSDS
Product group Chemicals
Estimated Purity>99%
Molecular Weight404.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Myxochelin A [120243-02-9]
  • Delivery Days Customer
    10
  • CAS Number
    120243-02-9
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Hazard Information
    Warning
  • Molecular Formula
    C20H24N2O7
  • Molecular Weight
    404.4
  • Scientific Description
    Chemical. CAS: 120243-02-9. Formula: C20H24N2O7. MW: 404.4. Synthetic. Originally isolated from Pyxidicoccus fallax HKI 727. Potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Iron-chelating compound. Anticancer antibiotic. Shown to inhibit tumor cell invasion in vitro. Antibacterial compound. Antioxidant with free radical scavenging activities. - Potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Iron-chelating compound. Anticancer antibiotic. Shown to inhibit tumor cell invasion in vitro. Antibacterial compound. Antioxidant with free radical scavenging activities.
  • SMILES
    OC[C@H](CCCCNC(=O)C1=C(O)C(O)=CC=C1)NC(=O)C1=CC=CC(O)=C1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties: B. Kunze, et al.; J. Antibiot. 42, 14 (1989)
  • Myxochelin A, a cytotoxic antibiotic from the myxobacterium Angiococcus disciformis: J.W. Ahn, et al.; OPEM 2, 64 (2001)
  • Antioxidative and free radical scavenging activities of Myxochelin A isolated from Angiococcus sp.(Myxobacteria): H.-H. Lee, et al.; Food Sci. Biotech. 11, 184 (2002)
  • Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861: S. Miyanaga, et al.; J. Antibiot. 59, 698 (2006)
  • Synthesis and evaluation of myxochelin analogues as antimetastatic agents: S. Miyanaga, et al.; Bioorg. Med. Chem. 17, 2724 (2009)
  • Myxochelins target human 5-lipoxygenase: S. Schieferdecker, et al.; J. Nat. Prod. 78, 335 (2015)
  • Harnessing enzymatic promiscuity in Myxochelin biosynthesis for the production of 5-Lipoxygenase inhibitors: J. Korp, et al.; Chembiochem. 16, 2445 (2015)