Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

N-(3-Oxododecanoyl)-DL-homoserine lactone

Research Use Only
CDX-O0032
Chemodex
Product group Chemicals
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Chemodex
  • Product Name
    N-(3-Oxododecanoyl)-DL-homoserine lactone
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    Chemical. CAS: 152833-54-0. Formula: C16H27NO4. MW: 297.39. Soluble in DMSO or chloroform. Quorum sensing agent. N-(3-Oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) is a small diffusible signaling molecule, also identified as P. aeruginosa autoinducer (PAI), and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention and formation of biofilms. 3-oxo-C12-HSL is one of the AHLs frequently identified in extracts of respiratory secretions from cystic fibrosis patients infected with P. aeruginosa. 3-oxo-C12-HSL activates the transcription factors NF-kappaB and AP-2 to induce interleukin-8, cyclooxygenase 2, and prostaglandin E2 production in human lung fibroblasts and epithelial cells, possibly contributing to the neutrophil infiltration and inflammation found in P. aeruginosa infections. 3-oxo-C12-HSL also suppresses human and murine leucocyte proliferation and inhibits LPS-induced secretion of TNF-R and IL-12. 3-oxo-C12-HSL accelerated apoptosis in mammalian macrophages and neutrophils and shown to inhibit the growth of human colorectal, breast and prostate cancer cells. - Quorum sensing agent. N-(3-Oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) is a small diffusible signaling molecule, also identified as P. aeruginosa autoinducer (PAI), and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention and formation of biofilms. 3-oxo-C12-HSL is one of the AHLs frequently identified in extracts of respiratory secretions from cystic fibrosis patients infected with P. aeruginosa. 3-oxo-C12-HSL activates the transcription factors NF-kappaB and AP-2 to induce interleukin-8, cyclooxygenase 2, and prostaglandin E2 production in human lung fibroblasts and epithelial cells, possibly contributing to the neutrophil infiltration and inflammation found in P. aeruginosa infections. 3-oxo-C12-HSL also suppresses human and murine leucocyte proliferation and inhibits LPS-induced secretion of TNF-R and IL-12. 3-oxo-C12-HSL accelerated apoptosis in mammalian macrophages and neutrophils and shown to inhibit the growth of human colorectal, breast and prostate cancer cells.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200