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N-Cadherin antibody [GC-4]

GTX11340
GeneTex
ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityChicken, Human, Mouse, Rabbit, Rat
TargetCDH2
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Overview

  • Supplier
    GeneTex
  • Product Name
    N-Cadherin antibody [GC-4]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:100. IHC-Fr: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Electron Microscopy, Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GC-4
  • Conjugate
    Unconjugated
  • Gene ID414745
  • Target name
    CDH2
  • Target description
    cadherin 2
  • Target synonyms
    cadherin 2, type 1, N-cadherin (neuronal); cadherin-2; N-cadherin; neural cadherin; neural calcium-dependent cell adhesion molecule
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP10288
  • Protein Name
    Cadherin-2
  • Scientific Description
    Monoclonal Anti-N Cadherin/ACAM may be used for the localization of a 135 kDa receptor of the intercellular adherens junction in immunofluorescent microscopy, electron microscopy, and immunoblotting. This antibody can also be used to study the mechanism of adhesion and interaction of cultured cells and cells in tissues.Monoclonal Anti-NCadherin/ACAM stains a large variety of intercellular junctions formed by chicken fibroblastic and epithelial cells in culture. In adult mammals, the antibody stains predominantly heart and lens tissue and also stains a large variety of embryonic tissue. By double labelling, this antibody appears to localize vinculin and actin-rich intercellular contacts and is absent from cellular matrix attachment sites.
  • Reactivity
    Chicken, Human, Mouse, Rabbit, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Kiel MJ et al., 2007 Aug 16, Cell Stem Cell
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  • N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Li G et al., 2001 May 1, Cancer Res
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