N-Desmethyl-loperamide

MedChem Express

N-Desmethyl-loperamide [66164-07-6]

5

66164-07-6

Research Use Only

C28H31ClN2O2

463.01

N-Desmethyl-loperamide is a major metabolite of loperamide, a drug that selectively activates peripheral microopioid receptors with a Ki value of 0.16 nM. N-Desmethyl-loperamide is a substrate of the ATP-dependent efflux transporter P-glycoprotein[1][2][3].

O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)NC

12352200