N-Desmethylclozapine

Selleck Chemicals

N-Desmethylclozapine

9

Research Use Only

N-Desmethylclozapine (Norclozapine, Normethylclozapine), a metabolite of the atypical antipsychotic drug Clozapine, is a potent, allosteric and partial agonist of M1 receptors with EC50 of 115 nM. N-Desmethylclozapine is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation and also a delta-opioid agonist.

12352200