n-Myc (Neuroblastoma Marker)(NMYC-1), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

n-Myc (Neuroblastoma Marker)(NMYC-1), CF594 conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

NMYC-1

0.1 mg/ml

Other Conjugate

MYCN

MYCN proto-oncogene, bHLH transcription factor

bHLHe37; class E basic helix-loop-helix protein 37; MODED; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; N-myc; N-myc proto-oncogene protein; ODED; oncogene NMYC; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog

Mouse

IgG2a

N-myc proto-oncogene protein

The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse, Rat

2°C to 8°C

12352203