NAADP (sodium salt)
T35922
Product group Chemicals
Overview
- SupplierTargetMol Chemicals
- Product NameNAADP (sodium salt)
- Delivery Days Customer999
- Category SupplierChemical
- Chemical NameNAADP (sodium salt)
- Scientific DescriptionNicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis. NAADP-induced calcium mobilization induces VEGF-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs). It also alkalizes lysosomal pH thereby inhibiting fusion between autophagosomes and lysosomes and arresting autophagic flux in mouse embryonic stem cells.
- Shelf life instruction3 years
- SMILES#N/A
- Storage Instruction-20°
- UNSPSC12352200