Naldemedine (tosylate)

MedChem Express

Naldemedine (tosylate)

10

Research Use Only

92.16

C39H42N4O9S

742.84

Naldemedine (S-297995) tosylate is an orally active micro-opioid receptor antagonist (PAMORA) [1] . Naldemedine tosylate shows potent binding affinities ( K i =0.34, 0.43, 0.94 nM, respectively) and antagonist activities ( IC 50 =25.57, 7.09, 16.1 nM, respectively) for recombinant human micro-, delta-, and kappa- opioid receptors [2] . Naldemedine can be used in opioid-induced constipation (OIC) research [2] . Naldemedine tosylate is predicted to bind to 3CL pro encoded by SARS-CoV2 genome [3] .

O[C@@]1(CC(C(NC(C)(C2=NC(C3=CC=CC=C3)=NO2)C)=O)=C4O)[C@@]([C@@]4([H])OC5=C6O)(CC7)C5=C(C=C6)C[C@@]1([H])N7CC8CC8.CC9=CC=C(S(=O)(O)=O)C=C9

-20°C

12352200