Nanog ELISA Pair

GeneTex

Nanog ELISA Pair

9

We recommend using the capture antibody at a concentration of 5microg/mL and the detection antibody at a concentration of 5microg/mL. Optimal dilutions should be determined experimentally by the researcher.

ELISA

Research Use Only

NANOG

Nanog homeobox

homeobox protein NANOG, homeobox transcription factor Nanog, homeobox transcription factor Nanog-delta 48

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5-TAAT[GT][GT]-3 or 5-[CG][GA][CG]C[GC]ATTAN[GC]-3 (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.

Human

-20°C or -80°C,2°C to 8°C

12352203