Nanos2 antibody

GeneTex

Nanos2 antibody

9

This antibody is specific for Nanos2 N-Terminus

WB: 1 - 2 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

1 mg/ml

Liquid

NANOS2

nanos C2HC-type zinc finger 2

nanos homolog 2; NOS2; NOS-2; ZC2HC12B

Nanos homolog 2

Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2- primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3- PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3- background. Nanos3 expression can not rescue Nanos2- defects. This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.

-20°C or -80°C,2°C to 8°C

12352203