Narmafotinib

MedChem Express

Narmafotinib [1393653-34-3]

10

1393653-34-3

Research Use Only

99.86

C28H32F3N5O2

527.58

Narmafotinib (AMP-945) is an orally active inhibitor of the enzyme focal adhesion kinase (FAK, KD=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC50=7 nM and exhibits low general cellular toxicity (IC50=2.7 microM, MDA-MB-231 cells). Narmafotinib can be used for anti-cancer study[1].

O=C(CC1=C(CCC2=NC(NC3=CC=C(C4CCN(CC4)C)C=C3OC)=NC=C2C(F)(F)F)C=CC=C1)N

2°C to 8°C

12352200