Nav1.7-IN-8 [1432913-44-4]

TargetMol Chemicals

Nav1.7-IN-8 [1432913-44-4]

999

1432913-44-4

Chemical

Research Use Only

Nav1.7-IN-8

C21H12ClF2N5O4S2

535.92

Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP2C9 and CYP3A4, with IC50 values of 0.17 microM and 0.077 microM, respectively. Notably, Nav1.7-IN-8 demonstrates significant analgesic properties in rodent models of both acute and inflammatory pain.

3 years

Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1

-20°C

51202000