Navitoclax (dihydrochloride)

MedChem Express

Navitoclax (dihydrochloride)

9

C47H57Cl3F3N5O6S3

1047.53

Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL , Bcl-2 , and Bcl-w , with a K i value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research [1] .

O=C(C1=CC=C(N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(Cl)C=C4)C=C1)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)=O.Cl.Cl

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