NAZ2329

MedChem Express

NAZ2329

10

Research Use Only

99.02

C21H18F3NO4S3

501.56

NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ ( IC 50 =7.5 microM for hPTPRZ1) and PTPRG ( IC 50 =4.8 microM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment ( IC 50 of 1.1 microM) than the whole intracellular (D1 + D2) fragment ( IC 50 of 7.5 microM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties [1] .

CCOC1=C(CSC2=C(C(NS(=O)(C3=CC=CC=C3)=O)=O)SC=C2)C=C(C(F)(F)F)C=C1

-20°C,2°C to 8°C

12352200