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NBI 35965 (hydrochloride)

HY-110056
MedChem Express
CAS Number1782228-59-4
DownloadMSDS
Product group Chemicals
Molecular Weight437.79
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NBI 35965 (hydrochloride) [1782228-59-4]
  • Delivery Days Customer
    14
  • CAS Number
    1782228-59-4
  • Certification
    Research Use Only
  • Molecular Formula
    C21H23Cl3N4
  • Molecular Weight
    437.79
  • Scientific Description
    NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K i value of 4 nM and a pK i value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC 50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects [1] [2] .
  • SMILES
    CC[C@H]1CN2N=C(C3=C(C=C(C=C3)Cl)Cl)C4=NC(C)=CC(N1CC5CC5)=C42.Cl
  • UNSPSC
    12352200