(+/-)-NBI-74330

MedChem Express

(+/-)-NBI-74330 [473722-68-8]

14

473722-68-8

Research Use Only

C32H27F4N5O3

605.58

(+/-)-NBI-74330 is a potent and selective CXCR3 antagonist. (+/-)-NBI-74330 not only reduces tactile and thermal hypersensitivity but also enhances the analgesic properties of morphine. (+/-)-NBI-74330 can reduce microglial cell activation, increase astroglial cell activation, and downregulate the expression of some CXCR3 ligands in a rat neuropathic pain model [1] .

O=C1C2=C(N=C(C(C)N(CC3=CC=CN=C3)C(CC4=CC=C(C(C(F)(F)F)=C4)F)=O)N1C5=CC=C(C=C5)OCC)N=CC=C2

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