NCATS-SM4420

MedChem Express

NCATS-SM4420

9

Research Use Only

C31H27N3O5

521.56

NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC50 values of 0.71 microM and 0.38 microM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer[1].

O=C(C)NC1=CC=C(C=C1)OCC2=C(OC)C=CC(C3=NC4=C(C(N3CC5=CC=CC=C5)=O)C(O)=CC=C4)=C2

12352200