NCC antibody

Biorbyt

NCC antibody

16

1 microg/ml of SPC-402 was sufficient for detection of NCC3 in 10 microg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

WB (1:1000), IHC (1:200) ICC, IEM, IHC, WB

Research Use Only

Polyclonal

1 mg/ml

PerCP

SLC12A3

solute carrier family 12 member 3

Na-Cl cotransporter; NaCl electroneutral thiazide-sensitive cotransporter; Na-Cl symporter; NCC; NCCT; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; TSC

Rabbit

Solute carrier family 12 member 3

Rabbit polyclonal to NCC (PerCP). NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis. Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC. Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension. Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat..

Canine, Human, Mouse, Rat

2°C to 8°C

12352203