NCF4 Polyclonal Antibody

Reddot Biotech

NCF4 Polyclonal Antibody

5

ImmunoFluorescence, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

NCF4

neutrophil cytosolic factor 4

CGD3; NCF; NCF-4; neutrophil cytosol factor 4; neutrophil cytosolic factor 4, 40kDa; neutrophil NADPH oxidase factor 4; P40PHOX; p40-phox; SH3 and PX domain-containing protein 4; SH3PXD4

Rabbit

IgG

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Human, Mouse, Rat

-20°C

12352203