NCSTN Polyclonal Antibody
RD267052A
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetNCSTN
Overview
- SupplierReddot Biotech
- Product NameNCSTN Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID23385
- Target nameNCSTN
- Target descriptionnicastrin
- Target synonymsanterior pharynx-defective 2; ATAG1874; nicastrin
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203