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NCX 466

HY-103388
MedChem Express
CAS Number1262956-64-8
Product group Chemicals
Molecular Weight436.41
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Overview

  • Supplier
    MedChem Express
  • Product Name
    NCX 466
  • Delivery Days Customer
    9
  • CAS Number
    1262956-64-8
  • Certification
    Research Use Only
  • Molecular Formula
    C20H24N2O9
  • Molecular Weight
    436.41
  • Scientific Description
    NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-beta ( TGF-beta ) and oxidative stress markers (such as thiobarbituric acid reactive substances ( TBARS ) and 8-hydroxy-2-deoxyguanosine ( 8-OHdG )), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase ( MPO ) activity, thereby preventing bleomycin (HY-108345)-induced pulmonary fibrosis in mice [1] .
  • SMILES
    O=C(OCCCC[C@H](O[N+]([O-])=O)CO[N+]([O-])=O)[C@H](C1=CC2=C(C=C(OC)C=C2)C=C1)C
  • UNSPSC
    12352200