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NDUFS1 antibody

GTX113787
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetNDUFS1
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Overview

  • Supplier
    GeneTex
  • Product Name
    NDUFS1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.57 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4719
  • Target name
    NDUFS1
  • Target description
    NADH:ubiquinone oxidoreductase core subunit S1
  • Target synonyms
    CI-75Kd, CI-75k, MC1DN5, PRO1304, NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), complex I 75kDa subunit, complex I, mitochondrial respiratory chain, 75-kD subunit, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP28331
  • Protein Name
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
  • Scientific Description
    The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Kuo TT, Lin LC, Chang HY, et al. Quantitative Proteome Analysis Reveals Melissa officinalis Extract Targets Mitochondrial Respiration in Colon Cancer Cells. Molecules. 2022,27(14). doi: 10.3390/molecules27144533
    Read this paper
  • Lobo-Jarne T, Pérez-Pérez R, Fontanesi F, et al. Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes. EMBO J. 2020,39(14):e103912. doi: 10.15252/embj.2019103912
    Read this paper
  • Fujimaki M, Furuya N, Saiki S, et al. Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions. Mol Cell Biol. 2019,39(14). doi: 10.1128/MCB.00010-19
    Read this paper
  • Ishiyama A, Sakai C, Matsushima Y, et al. IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy. Neurol Genet. 2017,3(5):e184. doi: 10.1212/NXG.0000000000000184
    Read this paper
  • Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, et al. COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation. Cell Rep. 2016,16(9):2387-98. doi: 10.1016/j.celrep.2016.07.081
    Read this paper
  • Lim SC, Hroudová J, Van Bergen NJ, et al. Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J. 2016,30(6):2236-48. doi: 10.1096/fj.201500137R
    Read this paper