NDUFS1 antibody
GTX113787
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetNDUFS1
Overview
- SupplierGeneTex
- Product NameNDUFS1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.57 mg/ml
- ConjugateUnconjugated
- Gene ID4719
- Target nameNDUFS1
- Target descriptionNADH:ubiquinone oxidoreductase core subunit S1
- Target synonymsCI-75Kd, CI-75k, MC1DN5, PRO1304, NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), complex I 75kDa subunit, complex I, mitochondrial respiratory chain, 75-kD subunit, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit
- HostRabbit
- IsotypeIgG
- Protein IDP28331
- Protein NameNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Scientific DescriptionThe protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Kuo TT, Lin LC, Chang HY, et al. Quantitative Proteome Analysis Reveals Melissa officinalis Extract Targets Mitochondrial Respiration in Colon Cancer Cells. Molecules. 2022,27(14). doi: 10.3390/molecules27144533Read this paper
- Lobo-Jarne T, Pérez-Pérez R, Fontanesi F, et al. Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes. EMBO J. 2020,39(14):e103912. doi: 10.15252/embj.2019103912Read this paper
- Fujimaki M, Furuya N, Saiki S, et al. Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions. Mol Cell Biol. 2019,39(14). doi: 10.1128/MCB.00010-19Read this paper
- Ishiyama A, Sakai C, Matsushima Y, et al. IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy. Neurol Genet. 2017,3(5):e184. doi: 10.1212/NXG.0000000000000184Read this paper
- Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, et al. COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation. Cell Rep. 2016,16(9):2387-98. doi: 10.1016/j.celrep.2016.07.081Read this paper
- Lim SC, Hroudová J, Van Bergen NJ, et al. Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J. 2016,30(6):2236-48. doi: 10.1096/fj.201500137RRead this paper



