Nebentan potassium

TargetMol Chemicals

Nebentan potassium

14

342005-82-7

Chemical

Nebentan potassium

C24H21KN5O5S

530.62

Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].

3 years

[K].COc1ccccc1Oc1c(NS(=O)(=O)\C=C\c2ccccc2)nc(nc1OC)-c1ncccn1

-20°

12352200