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ProductsBack/Necrostatin-5 (Nec-5) [337349-54-9]
Chemical Structure
Chemical Structure
Chemical Structure

Necrostatin-5 (Nec-5) [337349-54-9]

Research Use Only
AG-CR1-0049
AdipoGen Life Sciences
CAS Number337349-54-9
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight383.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Necrostatin-5 [337349-54-9]
  • Delivery Days Customer
    10
  • CAS Number
    337349-54-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C19H17N3O2S2
  • Molecular Weight
    383.5
  • Scientific Description
    Chemical. CAS: 337349-54-9. Formula: C19H17N3O2S2. MW: 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective - Necroptosis inhibitor [1]. Indirect RIP1 kinase inhibitor [2]. Cardioprotective
  • SMILES
    COC1=CC=C(C=C1)N1C(=O)C2=C(SC3=C2CCCC3)N=C1SCC#N
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5: K. Wang, et al.; Bioorg. Med. Chem. Lett. 17, 1455 (2007)
  • Idenfication of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008)
  • Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion: Y.V. Dimitriev, et al.; Bull. Exp. Biol. Med. 155, 245 (2013)