More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/NecroX-7 [1120332-55-9]
NecroX-7 [1120332-55-9]

NecroX-7 [1120332-55-9]

T9948
TargetMol Chemicals
Estimated Purity98.08%
DownloadMSDS
Product group Chemicals
Molecular Weight439.57
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    NecroX-7 [1120332-55-9]
  • Delivery Days Customer
    9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    NecroX-7
  • Estimated Purity
    98.08%
  • Molecular Formula
    C24H29N3O3S
  • Molecular Weight
    439.57
  • Scientific Description
    NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].
  • Shelf life instruction
    3 years
  • SMILES
    N(C1=C2C(C=C(N2)C3=CC=CC=C3)=CC(CN4CCS(=O)(=O)CC4)=C1)C5CCOCC5
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice. Grootaert MOJ et al., 2016 Sep, Atherosclerosis
    Read more