More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Nectin-2 Protein, Human, Recombinant (ECD, His Tag)
Nectin-2 Protein, Human, Recombinant (ECD, His Tag)

Nectin-2 Protein, Human, Recombinant (ECD, His Tag)

Research Use Only
10005-H08H
Sino Biological
DownloadDatasheet
Product group Proteins / Signaling Molecules
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    Sino Biological
  • Product Name
    Nectin-2 Protein, Human, Recombinant (ECD, His Tag)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
  • UNSPSC
    12352202

References

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
    Read more
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
    Read more