NEDD4L Antibody, FITC conjugated

Cusabio

NEDD4L Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

NEDD4L

NEDD4 like E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; NEDD4.2; NEDD4-2; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; PVNH7; RSP5; ubiquitin-protein ligase Rsp5

Rabbit

IgG

E3 ubiquitin-protein ligase NEDD4-like

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5 (PubMed:26363003). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961).

Human

-20°C or -80°C

12352203