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NEIL2 antibody

Name: NEIL2 antibody
SKU: GTX132565_G10
Availability: BackOrder

GTX132565

ApplicationsWestern Blot

Product group Antibodies

ReactivityHuman

TargetNEIL2

Overview

Supplier
GeneTex
Product Name
NEIL2 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.88 mg/ml
Conjugate
Unconjugated
Gene ID252969
Target name
NEIL2
Target description
nei like DNA glycosylase 2
Target synonyms
DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; endonuclease 8-like 2; NEH2; nei endonuclease VIII-like 2; nei homolog 2; NEI2; nei-like protein 2
Host
Rabbit
Isotype
IgG
Protein IDQ969S2
Protein Name
Endonuclease 8-like 2
Scientific Description
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM]
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
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The Role of Alternative Splicing Factors, DDB2-Related Ageing and DNA Damage Repair in the Progression and Prognosis of Stomach Adenocarcinoma Patients.
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The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. Sayed IM et al., 2020 Aug 28, Cells
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