Western blot analysis of extracts from COLO cells, HUVEC cells, HepG2 cells and HeLa cells, using NEIL3 antibody.
Western blot analysis of extracts from COLO cells, HUVEC cells, HepG2 cells and HeLa cells, using NEIL3 antibody.
NEIL3 Antibody
CSB-PA065468
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetNEIL3
Overview
- SupplierCusabio
- Product NameNEIL3 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID55247
- Target nameNEIL3
- Target descriptionnei like DNA glycosylase 3
- Target synonymsDNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; endonuclease 8-like 3; endonuclease VIII-like 3; FGP2; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; NEI3; nei-like protein 3; ZGRF3; zinc finger, GRF-type containing 3
- HostRabbit
- IsotypeIgG
- Protein IDQ8TAT5
- Protein NameEndonuclease 8-like 3
- Scientific DescriptionDNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. Takao M., J. Biol. Chem. 277:42205-42213(2002). Ota T., Nat. Genet. 36:40-45(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203