Neurofilament, phospho (NF-H) (Neuronal Marker)(NE14), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

Neurofilament, phospho (NF-H) (Neuronal Marker)(NE14), CF405S conjugate, 0.1mg/mL

9

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

NE14

0.1 mg/ml

Other Conjugate

NEFH

neurofilament heavy chain

200 kDa neurofilament protein; CMT2CC; neurofilament heavy polypeptide; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; NFH; NF-H

Mouse

IgG1

Neurofilament heavy polypeptide

This MAb reacts with a 200 kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). It reacts specifically with the phosphorylated KSP/KEP segment at the C-terminus of the heavy subunit (NF-H) of neurofilaments. After dephosphorylation of neurofilaments with alkaline phosphatase, this Ab no longer binds. Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L), 160 kDa (NF-M) and 200 kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

Animal

Bovine, Chicken, Feline, Gerbil, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat

2°C to 8°C

12352203