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ProductsBack/Neuromedin U-25 (human) [312306-89-1]
Chemical Structure
Chemical Structure
Chemical Structure

Neuromedin U-25 (human) [312306-89-1]

Research Use Only
AG-CP3-0031
AdipoGen Life Sciences
Estimated Purity>98%
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Product group Chemicals
Molecular Weight3080.4 . 114.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Neuromedin U-25 (human) [312306-89-1]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C141H203N41O38 . C2HF3O2
  • Molecular Weight
    3080.4 . 114.0
  • Scientific Description
    Active human form of NMU. Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS. The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling. Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes. Activator of innate lymphoid cells 2 (ILC2) during inflammation, as shown in studies in mice [6-8]. - Chemical. CAS: 312306-89-1. Formula: C141H203N41O38 . C2HF3O2. MW: 3080.4 . 114.0. Synthetic. Active human form of NMU. Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS. The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling. Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes. Activator of innate lymphoid cells 2 (ILC2) during inflammation, as shown in studies in mice.
  • SMILES
    C[C@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC3=CC=CC=C3)=O)CCC(N)=O)=O)CO)=O)=O)CC4=CC=CC=C4)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N)=O)CC(N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CC6=CC=CC=C6)=O)CC(C)C)=O)CC7=CC=CC=C7)=O)CC8=CC=C(O)C=C8)=O)=O)CCCNC(N)=N)=O)CO)=O)CCC(N)=O)=O)CO)=O.FC(F)(C(O)=O)F
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system: J.D. Mitchell, et al.; Cardiovasc. Res. 81, 353 (2009)
  • Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S: J.D. Mitchell, et al.; Br. J. Pharmacol. 158, 87 (2009) (Review)
  • Peptides and their potential role in the treatment of diabetes and obesity: H.C. Greenwood, et al.; Rev. Diabet. Stud. 8, 355 (2011) (Review)
  • Suppression of insulin production and secretion by a decretin hormone: R. W. Alfa, et al.; Cell Metab. 21, 323 (2015)
  • Neuromedin U: a multifunctional neuropeptide with pleiotropic roles: V.G. Martinez & L. O'Driscoll; Clin. Chem. 61, 471 (2015) (Review)
  • The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation: C.S.N. Klose, et al.; Nature 549, 282 (2017)
  • The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation: A. Wallrapp, et al.; Nature 549, 351 (2017)
  • Neuronal regulation of type 2 innate lymphoid cells via neuromedin U: V. Cardoso, et al.; Nature 549, 277 (2017)