Nevanimibe hydrochloride

MedChem Express

Nevanimibe hydrochloride [133825-81-7]

10

133825-81-7

99.92

C27H40ClN3O

458.08

Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 ( ACAT1 ) inhibitor with an EC 50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC 50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer [1] .

O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl

2°C to 8°C

12352200