NFAT1 (phospho Ser54) antibody

GeneTex

NFAT1 (phospho Ser54) antibody - Orthogonal Validated

9

ICC/IF: 1:250. FACS: 1:20. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

Nfatc2

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

AI607462; NF; NFA; NFAT pre-existing subunit; NFAT1; NFAT1-D; NF-ATc2; Nfatp; NF-ATp; nuclear factor of activated T-cells, cytoplasmic 2; T-cell transcription factor NFAT1

Rabbit

IgG

Nuclear factor of activated T-cells, cytoplasmic 2

Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT 1 (also known as NFATc2 or NFATp) is a 154 kDa member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT 1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT 1 has been shown to be important in the regulation of its transcriptional activity.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203