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GTX102090 ICC/IF Image
GTX102090 ICC/IF Image
GTX102090 ICC/IF Image

NFkB p65 antibody

Research Use Only
GTX102090
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    NFkB p65 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.3 mg/ml
  • Isotype
    IgG
  • Scientific Description
    NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • VHL Inactivation in Precancerous Kidney Cells Induces an Inflammatory Response via ER Stress-Activated IRE1alpha Signaling. Kuo CY et al., 2017 Jul 1, Cancer Res
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  • A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat Methods
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  • A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer. Tsai CH et al., 2017 Nov 15, Sci Rep
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  • An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. Wang S et al., 2013, PLoS Genet
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  • An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimers Disease. Chan HC et al., 2020 Nov 26, Biomedicines
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  • Anthocyanins and their gut metabolites attenuate monocyte adhesion and transendothelial migration through nutrigenomic mechanisms regulating endothelial cell permeability. Krga I et al., 2018 Aug 20, Free Radic Biol Med
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  • Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice. Zhang J et al., 2021, Mediators Inflamm
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  • Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-kappaB in a murine asthma model. Wang Z et al., 2019 Nov, Int Immunopharmacol
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  • Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis. Andreucci E et al., 2017 Dec, J Mol Med (Berl)
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  • Cell Free DNA of Tumor Origin Induces a Metastatic Expression Profile in HT-29 Cancer Cell Line. Furi I et al., 2015, PLoS One
    Read more