NFkB p65 antibody
GTX102090
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetRELA
Overview
- SupplierGeneTex
- Product NameNFkB p65 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.49 mg/ml
- ConjugateUnconjugated
- Gene ID5970
- Target nameRELA
- Target descriptionRELA proto-oncogene, NF-kB subunit
- Target synonymsAIF3BL3, CMCU, NFKB3, p65, transcription factor p65, NF-kappa-B p65delta3, NF-kappa-B transcription factor p65, nuclear factor NF-kappa-B p65 subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, v-rel avian reticuloendotheliosis viral oncogene homolog A
- HostRabbit
- IsotypeIgG
- Protein IDQ04206
- Protein NameTranscription factor p65
- Scientific DescriptionNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Hee SW, Chang YC, Su L, et al. 15-keto-PGE(2) alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors. iScience. 2023,26(10):107997. doi: 10.1016/j.isci.2023.107997Read this paper
- Arellano Buendia AS, Juárez Rojas JG, García-Arroyo F, et al. Antioxidant and anti-inflammatory effects of allicin in the kidney of an experimental model of metabolic syndrome. PeerJ. 2023,11:e16132. doi: 10.7717/peerj.16132Read this paper
- Huang SC, Wu WJ, Lee YJ, et al. Gastroprotective effects of Machilus zuihoensis Hayata bark against acidic ethanol-induced gastric ulcer in mice. J Tradit Complement Med. 2023,13(5):511-520. doi: 10.1016/j.jtcme.2023.05.006Read this paper
- Hasegawa Y, Asada S. DNA-dependent protein kinase catalytic subunit binds to the transactivation domain 1 of NF-κB p65. Biochem Biophys Rep. 2023,35:101538. doi: 10.1016/j.bbrep.2023.101538Read this paper
- Teramoto H, Hirashima N, Tanaka M. Calcineurin B1 Deficiency Reduces Proliferation, Increases Apoptosis, and Alters Secretion in Enteric Glial Cells of Mouse Small Intestine in Culture. Cells. 2023,12(14). doi: 10.3390/cells12141867Read this paper
- Yang JX, Zhu J, Ni K, et al. Electroacupuncture relieves chronic pain by promoting microglia M2 polarization in lumbar disc herniation rats. Neuroreport. 2023,34(12):638-648. doi: 10.1097/WNR.0000000000001935Read this paper
- Liu PI, Jiang YJ, Chang AC, et al. ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis. Aging (Albany NY). 2023,15(5):1652-1667. doi: 10.18632/aging.204581Read this paper
- Li CJ, Tsai HW, Chen YL, et al. Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2023,10:123-138. doi: 10.2147/JHC.S385238Read this paper
- Zhang W, Fan Z, Wang F, et al. Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3. Oxid Med Cell Longev. 2023,2023:9966355. doi: 10.1155/2023/9966355Read this paper
- Cardile A, Zanrè V, Campagnari R, et al. Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism. Int J Mol Sci. 2023,24(2). doi: 10.3390/ijms24021263Read this paper
Datasheet
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![IHC-P analysis of rat spleen tissue section using GTX00947 NFkB p65 antibody [GT1185]. Dilution : 1:100](https://www.genetex.com/upload/website/prouct_img/normal/GTX00947/GTX00947_20200327_IHC-P_13_w_23053121_725.webp)
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