NI-42
T16321
Overview
- SupplierTargetMol Chemicals
- Product NameNI-42
- Delivery Days Customer4
- CAS Number1884640-99-6
- Category SupplierChemical
- Chemical NameNI-42
- Molecular FormulaC18H15N3O3S
- Molecular Weight353.39
- Scientific DescriptionNI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins.
- Shelf life instruction3 years
- SMILESCN1C=2C(=CC(NS(=O)(=O)C3=CC=C(C#N)C=C3)=CC2)C=C(C)C1=O
- Storage Instruction-20°
- UNSPSC12352200
References
- Igoe N, et al. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680.Read more