NI-57 [1883548-89-7]

BPS Bioscience

NI-57 [1883548-89-7]

7

1883548-89-7

Research Use Only

C19H17N3O4

383.4 Da

NI-57 is a selective and potent inhibitor of BRPF (Bromodomain and PHD Finger) family of proteins (BRPF1/2/3). NI-57 shows Kd values of 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively. NI-57 also exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.

-20°C

12352200