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(+)-Niguldipine (hydrochloride)

HY-101390
MedChem Express
CAS Number113145-69-0
Product group Chemicals
Estimated Purity98.06
Molecular Weight646.17
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (+)-Niguldipine (hydrochloride) [113145-69-0]
  • Delivery Days Customer
    5
  • CAS Number
    113145-69-0
  • Certification
    Research Use Only
  • Estimated Purity
    98.06
  • Molecular Formula
    C36H40ClN3O6
  • Molecular Weight
    646.17
  • Scientific Description
    (+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID 50 of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with K i of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED 30 of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias [1] .
  • SMILES
    O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.Cl
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200