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(-)-Niguldipine (hydrochloride)

HY-101390A
MedChem Express
CAS Number113145-70-3
Product group Chemicals
Molecular Weight646.17
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (-)-Niguldipine (hydrochloride)
  • Delivery Days Customer
    9
  • CAS Number
    113145-70-3
  • Certification
    Research Use Only
  • Molecular Formula
    C36H40ClN3O6
  • Molecular Weight
    646.17
  • Scientific Description
    (-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts ( pID 50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes ( K i of 8.10), and lowers blood pressure in spontaneously hypertensive rats ( pED 30 of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias [1] .
  • SMILES
    O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.Cl
  • UNSPSC
    12352200