Nilotinib [641571-10-0]
N3346
Estimated Purity≥98%
Product group Chemicals
Overview
- SupplierLKT Laboratories
- Product NameNilotinib [641571-10-0]
- Delivery Days Customer7
- CertificationResearch Use Only
- Estimated Purity≥98%
- Scientific DescriptionPhenylamino pyridine; Abl, c-Kit, PDGFR, PP2A inhibitor.; AMN 107, Tasigna
- Storage InstructionAmbient
- UNSPSC12352200
References
- Shaker ME, Ghani A, Shiha GE, et al. Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases. Biochim Biophys Acta. 2013 Aug;1833(8):1992-2003. PMID: 23499874. Yu HC, Lin CS, Tai WT, et al. Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation. J Biol Chem. 2013 Jun 21;288(25):18249-59. PMID: 23677989. El-Agamy DS. Anti-allergic effects of nilotinib on mast cell-mediated anaphylaxis like reactions. Eur J Pharmacol. 2012 Apr 5;680(1-3):115-21. PMID: 22329898. Fabbro D, Manley PW, Jahnke W, et al. Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site. Biochim Biophys Acta. 2010 Mar;1804(3):454-62. PMID: 20152788. Quintás-Cardama A, Cortes J. Nilotinib: a phenylamino-pyrimidine derivative with activity against BCR-ABL, KIT and PDGFR kinases. Future Oncol. 2008 Oct;4(5):611-21. PMID: 18922118.