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Nitracrine (hydrochloride)

HY-U00279B
MedChem Express
Molecular Weight360.84
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Nitracrine (hydrochloride)
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C18H21ClN4O2
  • Molecular Weight
    360.84
  • Scientific Description
    Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions and is approximately 100,000 times more potent than misonidazole. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect[1].
  • SMILES
    O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN(C)C)=C21)[O-].Cl
  • UNSPSC
    12352200