Nitrotyrosine Antibody: APC

Biorbyt

Nitrotyrosine antibody

16

0.7 microg/ml of SMC-154 was sufficient for detection of 5 microg SIN-1 treated BSA by Western Blot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1400), IHC (1:100) ICC, IF, IHC

Research Use Only

Monoclonal

39B6

1 mg/ml

APC (Allophycocyanin)

Mouse

IgG2a

Mouse monoclonal to Nitrotyrosine (APC). Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury. The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimers disease, Parkinsons disease and amyotrophic lateral sclerosis..

All Species

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12352203