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Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of GTX41968. OM:Outer Medulla
Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of GTX41968. OM:Outer Medulla
Western blot analysis of NKCC2 in rat kidney tissue using a 1:1000 dilution of GTX41968. OM:Outer Medulla

NKCC2 antibody

GTX41968
GeneTex
ApplicationsWestern Blot
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSlc12a1
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Overview

  • Supplier
    GeneTex
  • Product Name
    NKCC2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    We recommend a working dilution of 1:1000 (WB).
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID25065
  • Target name
    Slc12a1
  • Target description
    solute carrier family 12 member 1
  • Target synonyms
    BSC1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; kidney-specific Na-K-Cl symporter; Nkcc2; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1; Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Exacerbation of celecoxib-induced renal injury by concomitant administration of misoprostol in rats. Cooper DL et al., 2014, PLoS One
    Read more
  • Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. Toka HR et al., 2012 Nov, J Am Soc Nephrol
    Read more