NKL 22 [537034-15-4]

MedChem Express

NKL 22 [537034-15-4]

5

537034-15-4

Research Use Only

97.27

C19H23N3O2

325.40

NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 microM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntingtons disease transgenic mice[1][2][3].

O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O

-20°C,2°C to 8°C

12352200