NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) (rNX2/294), 1mg/mL [26628-22-8]

Biotium

NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) (rNX2/294), 1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

rNX2/294

1 mg/ml

NKX2-2

NK2 homeobox 2

homeobox protein NK-2 homolog B; homeobox protein Nkx-2.2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; NKX2.2; NKX2B

Mouse

IgG2b

Homeobox protein Nkx-2.2

Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Chicken, Human, Mouse, Rat

-20°C

12352203