NLRP3 (Internal) blocking peptide
GTX89303-PEP
Product group Proteins / Signaling Molecules
Overview
- SupplierGeneTex
- Product NameNLRP3 (Internal) blocking peptide
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represente
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352202