Brophenexin (free base)

MedChem Express

NMDAR/TRPM4-IN-2 (free base) [1353979-43-7]

10

1353979-43-7

Research Use Only

99.24

C11H17BrN2

257.175

Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC 50 of 2.1 microM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss [1] .

NCCN(CC1=CC=CC(Br)=C1)CC

-20°C,2°C to 8°C

12352200