NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis)(CPTC-NME1-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis)(CPTC-NME1-2), CF405S conjugate, 0.1mg/mL

9

Western Blot

Research Use Only

Monoclonal

CPTC-NME1-2

0.1 mg/ml

Other Conjugate

NME1

NME/NM23 nucleoside diphosphate kinase 1

AWD; epididymis secretory sperm binding protein; GAAD; granzyme A-activated DNase; metastasis inhibition factor nm23; NB; NBS; NDKA; NDP kinase A; NDPKA; NDPK-A; NM23; NM23-H1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; tumor metastatic process-associated protein

Mouse

IgG2a

Nucleoside diphosphate kinase A

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP-K). In humans, NDP kinase A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203