Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

N,N,N,N-Tetrakis(2-pyridylmethyl)ethylenediamine [16858-02-9]

Research Use Only
CDX-T0044
Chemodex
CAS Number16858-02-9
Product group Chemicals
Estimated Purity>95%
Molecular Weight424.5
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Chemodex
  • Product Name
    N,N,N,N-Tetrakis(2-pyridylmethyl)ethylenediamine [16858-02-9]
  • Delivery Days Customer
    10
  • CAS Number
    16858-02-9
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C26H28N6
  • Molecular Weight
    424.5
  • Scientific Description
    Chemical. CAS: 16858-02-9. Formula: C26H28N6. MW: 424.5. TPEN is a cell permeable metal ion chelator. TPEN is a chelator that has a high affinity for zinc (Zn2+), next to other transition metals (Zn2+ >Fe2+ >Mn2+) and is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. TPEN has lower affinity for Ca2+ and Mg2+ and can also form complexes with other soft metal ions such as Cd2+. In addition to a heavy metal chelator, TPEN is also known to be an apoptosis inducer. Depletion of zinc by TPEN induces apoptosis in several cell lines. TPEN shows anticancer activity through induction of caspase-dependent apoptosis, via reactive oxygen species (ROS) signaling mechanism and inhibiting cell autophagy. TPEN also inhibits RNA binding protein Lin28 and has been shown to be useful in extracting Abeta depostis from Alzheimers disease brain tissue. - TPEN is a cell permeable metal ion chelator. TPEN is a chelator that has a high affinity for zinc (Zn2+), next to other transition metals (Zn2+ >Fe2+ >Mn2+) and is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. TPEN has lower affinity for Ca2+ and Mg2+ and can also form complexes with other soft metal ions such as Cd2+. In addition to a heavy metal chelator, TPEN is also known to be an apoptosis inducer. Depletion of zinc by TPEN induces apoptosis in several cell lines. TPEN shows anticancer activity through induction of caspase-dependent apoptosis, via reactive oxygen species (ROS) signaling mechanism and inhibiting cell autophagy. TPEN also inhibits RNA binding protein Lin28 and has been shown to be useful in extracting Abeta depostis from Alzheimers disease brain tissue.
  • SMILES
    N(CC1=CC=CC=N1)(CC2=CC=CC=N2)CCN(CC3=NC=CC=C3)CC4=CC=CC=N4
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200