NOD1/2-IN-1

MedChem Express

NOD1/2-IN-1

9

Research Use Only

C22H25N5O2S

423.53

NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor with an IC50 value of 1.4 nM, as determined by the ADP-Glo assay. NOD1/2-IN-1 blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathways, with IC50 values of 18 nM and 170 nM for NOD1 and NOD2, respectively, thereby reducing inflammatory responses. NOD1/2-IN-1 can be used in studies related to colitis[1].

COC1=CC2=C(C=C1OCCN(CC)CC)N=CN=C2NC3=CC=C4SC=NC4=C3

12352200